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SIRP beta

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SIA-H5257 Human Human SIRP beta / CD172b Protein, Fc Tag (MALS verified)
SIA-H5257-structure
SIA-H5257-sds
ACRO Quality

Part of Bioactivity data

SIA-H5257-BLI
Human SIRP beta, Fc Tag (Cat. No. ) MALS images

The purity of Human SIRP beta, Fc Tag (Cat. No. SIA-H5257) is more than 90% and the molecular weight of this protein is around 130-158 kDa verified by SEC-MALS.

Report
  • Background
    Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRPβ1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. SIRPβ1 is a transmembrane protein that has three Ig-like domains in its extracellular region and a short cytoplasmic tail. Human SIRPβ1 is expressed on monocytes and granulocytes but not on lymphocytes. SIRP beta 1 contains short cytoplasmic domains that lack cytoplasmic sequence motifs capable of recruiting SHP-2 and SHP-1. In addition, they contain a single basic lysine residue within the hydrophobic transmembrane domain.
  • Clinical and Translational Updates
      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

CD172b antigen, CD172b, DKFZp686A05192, FLJ26614, SIRP beta 1, SIRPB1, SIRP-BETA-1, 9930027N05Rik, SIRP-beta

Background

Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRP?1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. SIRP?1 is a transmembrane protein that has three Ig-like domains in its extracellular region and a short cytoplasmic tail. Human SIRP?1 is expressed on monocytes and granulocytes but not on lymphocytes. SIRP beta 1 contains short cytoplasmic domains that lack cytoplasmic sequence motifs capable of recruiting SHP-2 and SHP-1. In addition, they contain a single basic lysine residue within the hydrophobic transmembrane domain.

Clinical and Translational Updates

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